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101.
Lacking labeled examples of working numerical strategies, adapting an iterative solver to accommodate a numerical issue, e.g., density discontinuities in the pressure Poisson equation, is non-trivial and usually involves a lot of trial and error. Here, we resort to evolutionary neural network. A evolutionary neural network observes the outcome of an action and adapts its strategy accordingly. The process requires no labeled data but only a measure of a network's performance at a task. Applying neuro-evolution and adapting the Jacobi iterative method for the pressure Poisson equation with density discontinuities, we show that the adapted Jacobi method is able to accommodate density discontinuities. 相似文献
102.
103.
Injectable hydrogels for nonsteroidal anti‐inflammatory drugs’ (NSAIDs) delivery to minimize the side effects of NSAIDs and achieve long‐term sustained release at the targeted site of synovial joint are attractive for osteoarthritis therapy, but how to improve its mechanical strength remains a challenge. In this work, a kind of 1D natural clay mineral material, attapulgite (ATP), is introduced to a classical cyclodextrin pseudopolyrotaxane (PPR) system to form a reinforced supramolecular hydrogel for sustained release of diclofenac sodium (DS) due to its rigid, rod‐like morphology, and unique structure, which has great potential in tissue regeneration, repair, and engineering. Investigation on the interior morphology and rheological property of the obtained hydrogel points out that the ATP distributed in PPR hydrogel plays a role similar to the “reinforcement in concrete” and exhibits a positive effect on improving the mechanical properties of PPR hydrogel by regulating their interior morphology from a randomly distributed style to the well‐ordered porous frame structure. The hybrid hydrogels demonstrate good shear‐thinning and thixotropic properties, excellent biocompability, and sustained release behavior both in vitro and in vivo. Furthermore, preliminary in vivo treatment in an acute inflammatory rat model reveals that the ATP hybrid hydrogels present sustained anti‐inflammatory effect. 相似文献
104.
Yuyan Shi Xiaoyi Fu Prof. Yao Yin Fangqi Peng Xia Yin Prof. Guoliang Ke Prof. Xiaobing Zhang 《化学:亚洲杂志》2021,16(8):857-867
Clustered regularly interspaced short palindromic repeats (CRISPR) is a promising technology in the biological world. As one of the CRISPR-associated (Cas) proteins, Cas12a is an RNA-guided nuclease in the type V CRISPR-Cas system, which has been a robust tool for gene editing. In addition, due to the discovery of target-binding-induced indiscriminate single-stranded DNase activity of Cas12a, CRISPR-Cas12a also exhibits great promise in biosensing. This minireview not only gives a brief introduction to the mechanism of CRISPR-Cas12a but also highlights the recent developments and applications in biosensing and gene regulation. Finally, future prospects of the CRISPR-Cas12a system are also discussed. We expect this minireview will inspire innovative work on the CRISPR-Cas12a system by making full use of its features and advantages. 相似文献
105.
Journal of Visualization - The increasing availability of spatiotemporal data provides unprecedented opportunities for understanding the structure of an urban area in terms of people’s... 相似文献
106.
Guo Yan Li Zhuang Wei Yuxi Zhang Xinxu Shi Kexin 《Journal of Solid State Electrochemistry》2022,26(4):1051-1065
Journal of Solid State Electrochemistry - Polyvinylpyrrolidone (PVP) and graphene (G)-modified iron oxides (Fe2O3-PVP-G) are prepared by a simple hydrothermal reaction. Their morphology and... 相似文献
107.
Preparation and in vivo imaging of a novel potential αvβ3 targeting PET/MRI dual-modal imaging agent
Shi Xudong Sun Yulin Shen Langtao 《Journal of Radioanalytical and Nuclear Chemistry》2022,331(9):3485-3494
Journal of Radioanalytical and Nuclear Chemistry - Multi-modal biomedical imaging has played an essential role in tumor diagnosis. However, constructing a multi-modal imaging contrast agent with... 相似文献
108.
Reaction of 4,4′,4″-nitrilotribenzoic acid (H3L), a C3-symmetric ligand, with the divalent Co(II) salt Co(NO3)2·6H2O in the present of the N-donor ligand 1,2-di(4-pyridyl)ethylene (DPE) affords a new mixed-ligand coordination polymer with the chemical formula of [Co3(TNB)(DPE)2]·2H2O·DMF (1). In this study, CCK-8 assay was used to determine the effect of novel compound on proliferation of gastric cancer cells. The VEGF signaling pathway in gastric cancer cells was determined through employing real-time PCR after treatment of the above complex. Further, molecular docking simulation confirmed that the biological activity was coming from the carboxyl groups through the hydrogen bonding interactions with the receptor protein, the pyridine group only bonded with the Co ion for the formation of the Co complex. 相似文献
109.
Liu Wenbin Huang Yiwei Huang Guolin Fan Lijiao Xie Yuming Shi Jeffery 《Journal of Radioanalytical and Nuclear Chemistry》2022,331(5):2055-2068
Journal of Radioanalytical and Nuclear Chemistry - Eco-friendly and low-cost composite, amidoxime-functionalized microcrystalline cellulose/mesoporous silica (MCC/MS-AO), were synthesized by... 相似文献
110.
Jingqiu Zhang Mingrui Jiang Zhuzhu Yue Zhicheng Wang Huinan Wang Mengyu Chen Xiaotong Wei Shuanghui Shi Menglin Wang Yingzi Wang 《Biomedical chromatography : BMC》2022,36(8):e5394
Previous pharmacological studies have indicated that diterpenoids are the primary effective chemical cluster in the seeds of Euphorbia lathyris L. The seed products are used in traditional Chinese medicine in the forms of Semen Euphorbiae (SE) and Semen Euphorbiae Pulveratum (SEP). However, the metabolism of the plant's diterpenoids has not been well elucidated, which means that the in vivo metabolite products have not been identified. The current study screened the physiological metabolites of six diterpenes [Euphorbia factor L1 (L1), L2 (L2), L3 (L3), L7a (L7a), L7b (L7b), and L8 (L8)] in feces and urine of rats after oral administration of SE and SEP using UHPLC-Q-Exactive MS. A total of 22 metabolites were detected in feces and 8 in urine, indicating that the major elimination route of diterpenoids is via the colon. Hydrolysis, methylation, and glucuronidation served as the primary metabolic pathways of these diterpenoids. In sum, this study contributed to the elucidation of new metabolites and metabolic pathways of SE and SEP, and the new chemical identities can be used to guide further pharmacokinetic studies. 相似文献